IntroductionOsteogenesis imperfecta (OI) is a congenital skeletal disorder characterized by bone fragility.Bisphosphonates (BISs) have become the mainstream treatment in children with OI.However, an optimal treatment protocol has not yet been established, while BIS treatment tends to be administered to normalize bone mineral density (BMD).Bone qual
Abstract Background With over 500,000 annually reported cases Bath Cup worldwide, head and neck cancer (HNC) is the seventh most common type of cancer worldwide.Treatment of HNC with chemoradiotherapy frequently results in serious impairments in physical and psychosocial functioning.Besides, HNC patients typically start their cancer treatment alrea
Compressive mechanical stress produced during growth in a confining matrix limits the size of tumor spheroids, but little is known about the dynamics of stress accumulation, how the stress affects ORG CORNMEAL MEDIUM cancer cell phenotype, or the molecular pathways involved.We co-embedded single cancer cells with fluorescent micro-beads in agarose
Abstract Background Exceptional preservation of endogenous organics such as collagens and blood vessels has been frequently reported in Mesozoic dinosaur fossils.The persistence of these soft tissues in Mesozoic fossil bones has been challenged because Ice Cream Scoop of the susceptibility of proteins to degradation and because bone porosity allows